Elsewhere, Christian Bale's 'Hostiles' expands nationwide, while a flurry of films landing Oscar nominations look for a bump.
Maze Runner: The Death Cure should have no trouble sprinting to the top of the North American box office this weekend with a debut of $20 million or more.
The threequel is the final installment in the successful YA film series adapted from James Dashner's dystopia-themed books.
From 20th Century Fox, Death Cure was originally set to hit theaters a year ago, but its release was delayed when franchise star Dylan O'Brien suffered an injury while filming. Wes Ball directed all three films, the last of which, Maze Runner: The Scorch Trials, launched to $30.6 million in September 2015. The first outing, The Maze Runner, opened to $32.5 million in September 2014.
This time out, the Gladers travel to the villainous WCKD headquarters to rescue their friends.
Death Cure is also making a play overseas, where it took in a solid $15 million from a handful or markets.